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Neuroscience Graduate Program at UCSF

Faculty - Arnold R. Kriegstein, M.D./Ph.D.

Neural Stem Cells and Embryonic Cortical Development


Research Description

Research in our lab focuses on the way in which neural stem and progenitor cells produce neurons, and ways in which this information can be used for cell based therapies to treat diseases of the nervous system.  We found that radial glial cells, long thought to simply guide nerve cells during migration, are neuronal stem cells in the developing brain.  We also found a second type of nerve cell precursor produced by radial glial cells suggesting a new mechanism for the generation of cell diversity and potential new strategies for generating specific neuronal subtypes.  Recent insights gained from studies of the developing human cerebral cortex are illuminating potential evolutionary steps that contributed to structural and functional features of the human brain, as well as neurodevelopmental events that underlie a spectrum of cortical disorders including autism, schizophrenia, and epilepsy.  Unlike the developing rodent cortex, the developing human cortex contains a massively expanded outer proliferative zone that is thought to account for the bulk of cortical neurogenesis.  We have begun to characterize the types of progenitor cells within this progenitor region, to determine the genetic profiles of specific progenitor populations, and to explore how these cells contribute to the huge expansion of neuron number that characterize the human cerebral cortex.

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Lab Members

Jiadong Chen
Caitlyn Gertz
Corey Harwell
Bridget Lamonica
Jan Hsi Lui
Cory Nicholas
Lakshmi Subramanian
William Walantus
Xioqun Wang
Yingying Wang

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Selected Publications

Noctor, S.C., Flint, A.C., Weissman, T.A., Dammerman, R.S., & Kriegstein, A.R., Neurons derived from radial glial cells establish radial units in neocortex, Nature, 409:714-20, 2001.

Noctor, S. C., Martínez-Cerdeño, V, Ivic, L, Kriegstein, A.R., Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases, Nature Neuroscience, 7:136-44, 2004.

Hansen, D.V., Lui, J.H., Parker, P.R., Kriegstein, A.R., Neurogenic radial glia in the outer subventricular zone of human neocortex, Nature, 464:554-561, 2010.

Wang, X., Tsai, J.W., LaMonica, B., Kriegstein, A.R., A new subtype of progenitor cell in the mouse embryonic neocortex, Nat Neurosci., 14:555-61, Epub 2011 Apr 10, 2011

Lui, J.H., Hansen, D.V., Kriegstein, A.R., Development and Evolution of the Human Neocortex, Cell, 146:18-36, 2011.

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Arnold R. Kriegstein, M.D./Ph.D.



Email

kriegsteina@stemcell.ucsf.edu

Phone

415-476-0766

Office Address

UCSF MC 0524
35 Medical Center Way
RMB 1038
San Francisco CA 94143

Other Websites

Biomedical Sciences Graduate Program

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research

Developmental & Stem Cell Biology Graduate Program

PIBS Website