Clinical Profile Clinical Profile Clinical Profile ul
UCSF home page UCSF home page About UCSF UCSF Medical Center
UCSF navigation bar

Neuroscience Graduate Program at UCSF

Faculty - Karunesh Ganguly

Neuroprosthetics, motor rehabilitation, and plasticity

Research Description

The motor network is a highly adaptive and distributed system of interconnected cortical and subcortical areas. We aim to take a systems level perspective to understand motor learning/control under normal as well as pathological conditions such as stroke.  Recordings from intact animals support the conceptual framework for cortical processing such as synchronized oscillations, propagating waves of depolarization and cross-area inhibitions as playing a role in normal control.  How areas are recruited and whether these same conceptual frameworks are important for the process of creating reliable neuroprosthetics as well as for motor recovery after injury remains incompletely understood.  Using in vivo electrophysiological tools, we aim to characterize the network basis of recovery.  We also hope to use this information to create interfaces that can improve function.

Back to Top

Current Projects

Back to Top

Lab Members

Tanuj Gulati, Postdoctoral Fellow
Dhakshin Ramanathan, Postdoctoral Fellow
Jason Godlove, Postdoctoral Fellow
Lydia Reznichenko, Postdoctoral Fellow
Adelyn Tsu, Clinical and Research Fellow
Chelsea Wong, Research Associate

Back to Top

Selected Publications

Gulati T, Ramanathan DS, Wong CC and Ganguly K. Reactivation of emergent task-related ensembles during slow-wave sleep after neuroprosthetic learning. Nature Neuroscience. (2014).

Ganguly K and Poo MM.  Activity-dependent neural plasticity from bench to bedside.  Neuron (2013).  80(3): 729-41.

Ganguly K, Byl, NN and Abram, GM.  Neurorehabilitation: Motor recovery after stroke as an example.  Annals of Neurology (2013). 74(3). 373-381.

Ganguly K, Wallis JD and Carmena JM.  Reversible large-scale reshaping of cortical networks during neuroprosthetic control.  (2011) Nature Neuroscience 14, 662–667.

Ganguly K and Carmena JM.   Neural correlates of skill acquisition with a brain-machine interface.  (2010) Journal of Motor Behavior. 42, 355-360.

Canolty  R, Ganguly K, Kennerley S, Cadieu C, Koepsell K, Wallis L, Carmena J. Oscillatory phase coupling coordinates anatomically-dispersed functional cell assemblies. (2010) Proc. Natl Acad Sci U S A. 10.1073/pnas.1008306107.

Ganguly K and Carmena JM.  Emergence of a cortical map for neuroprosthetic function.  (2009) PLoS Biology 7, 1-13. e1000153.

Ganguly K, Secundo L, Ranade R, Orsborn A, Chang EF, Dimitrov DF, Wallis JD, Barbaro NM, Knight RT and Carmena JM.  Ensemble representation of ipsilateral arm movements in monkey and man.  (2009) Journal of Neuroscience 29(41):12948-12956. 

Woodin MA, Ganguly K and Poo M-m. Coincident Pre- and Postsynaptic Activity Modifies GABAergic Synapses by Postsynaptic Changes in Cl− Transporter Activity.  (2003) Neuron.  39, 807-820

Ganguly K and Kleinfeld D. Goal-directed whisking increases phase-locking between movement and electrical activity in primary sensory cortex in rat.  (2004) Proc Natl Acad Sci  101,12348-53.

Ganguly K, Schinder AF, Wong, ST and Poo M-m. GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition. (2001) Cell 105, 21-32.

Ganguly K, Kiss L and Poo M-m. Enhancement of presynaptic neuronal excitability by correlated presynaptic and postsynaptic spiking. (2000) Nature Neuroscience. 10, 18-26.

Back to Top

Karunesh Ganguly, MD, PhD




Office Address

1700 Owens Street, Rm 479
San Francisco, CA 94158

Other Websites

Lab Website