Neuroscience Graduate Program at UCSF
Cortical-subcortical networks for sensory processing and behavior
My lab aims to understand how sensory input is represented in the brain and transformed into behavioral commands. We study this problem in the superior colliculus (SC), a structure comprising functionally diverse sensory and motor neurons interleaved with fibers from myriad cortical and subcortical areas. This remarkable neuroanatomy poises the SC as an integrative hub, but has also hindered efforts to dissect SC circuitry using classical methods, such as lesions, that offer poor spatial and temporal resolution. In order to record from and manipulate genetically defined cell types, we study the mouse SC, where we capitalize on an experimental preparation I developed (Feinberg and Meister, Nature, 2015) that allows two-photon imaging of neuronal population activity in the SC of awake animals. We apply these methods to decipher computations in the context of quantitative behavioral assays. Our long-term goal is to understand how the brain encodes information from input to output.
See research description
Mayra Melville, Administrative Assistant
Feinberg, E.H. and Meister, M. Orientation columns in the mouse superior colliculus. Nature, 519(7542): 229-32.
Feinberg, E.H., Vanhoven, M.K., Bendesky, A., Wang, G., Fetter, R.D., Shen, K., and Bargmann, C.I. (2008) GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems. Neuron. 57(3):353-63.
Feinberg, E.H. and Hunter, C.P. (2003) Transport of dsRNA into cells by the transmembrane protein SID-1. Science. 301(5639): 1545-1547.